自噬现象广泛存在于所有真核生物中,是一种在正常或病理状态下细胞中普遍存在的生理机制。在哺乳动物卵巢中,不到1%的卵泡能完成排卵,大多数卵泡发生闭锁,自噬和细胞凋亡共同参与调节卵巢卵泡的发育和闭锁,自噬在原始卵泡和初级卵泡闭锁中可能发挥非常重要的作用。自噬发生于哺乳动物卵巢的颗粒细胞、膜细胞和卵母细胞,其中颗粒细胞是发生自噬的主要细胞,与细胞凋亡密切相关。 Autophagy is widespread in all eukaryotes and is a common physiological mechanism in cells under normal or pathological conditions. In mammalian ovary, less than 1% of ovarian follicles can complete ovulation. Most follicles undergo atresia, and autophagy and apoptosis participate in the regulation of ovarian follicle development and atresia. Autophagy may play an important role in primordial and primary follicular atresia Very important role. Autophagy occurs in mammalian ovarian granulosa cells, membrane cells and oocytes, of which granulosa cells are the major autophagic cells that are closely related to apoptosis.