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目的探讨血清总前列腺特异性抗原(tPSA)、血清游离前列腺特异性抗原(fPSA)与总特异性抗原比值(f/tPSA)在前列腺癌中的诊断价值。方法回顾性分析2013年1月—2016年12月年间在唐山市工人医院行前列腺系统性穿刺活检或经尿道前列腺电切术的701例患者,按照病理结果将其分为前列腺癌组(Pca组)和前列腺增生组(BPH组),比较不同tPSA水平二组患者tPSA与f/tPSA比值的差异。结果当tPSA≤4ng/ml时,二组患者的tPSA、f/tPSA比值差异无统计学意义(P>0.05);当4ng/ml0.05),而f/tPSA比值在Pca组明显低于BPH组,差异有统计学意义(P<0.05);当tPSA>10ng/ml,二组患者的tPSA、f/tPSA比值的差异均具有统计学意义。结论 PSA是前列腺癌的肿瘤标志物,在测定tPSA的同时联合检测f/tPSA比值,有助于灰区内前列腺癌的诊断。
Objective To investigate the diagnostic value of serum total prostate specific antigen (tPSA), serum free prostate-specific antigen (fPSA) and total specific antigen ratio (f / tPSA) in prostate cancer. Methods A retrospective analysis of 701 patients who underwent prostate biopsy or transurethral resection of prostate in Tangshan Workers’ Hospital from January 2013 to December 2016 was retrospectively analyzed. The patients were divided into the prostate cancer group (Pca group) ) And benign prostatic hyperplasia group (BPH group). The differences of tPSA and f / tPSA between two groups at different tPSA levels were compared. Results When tPSA≤4ng / ml, there was no significant difference in tPSA and f / tPSA ratio between the two groups (P> 0.05). When 4ng / ml 0.05), while the ratio of f / tPSA in Pca group was significantly lower than that in BPH group (P <0.05). When tPSA> 10ng / ml, the tPSA, f / tPSA Differences were statistically significant. Conclusions PSA is a tumor marker for prostate cancer. Combined detection of f / tPSA ratio in the determination of tPSA is helpful for the diagnosis of prostate cancer in the gray zone.