论文部分内容阅读
目的:探讨树突状细胞(DC)在变应性鼻炎实验小鼠发病中的可能作用及机制。方法:采用CpGoligodeoxynucleotide(CpGODN1826)培养诱导变应性鼻炎实验小鼠静脉血DC,进而检测DC协同刺激分子CD80、CD86的表达,以及其分泌的IL10、IL12等水平的变化。结果:实验小鼠静脉血DC其分泌IL10水平(3.6±0.5)μg/L明显低于对照组(6.8±0.8)μg/L,差异有统计学意义(t=20.608,P<0.01);分泌IL12水平(29.5±6.4)ng/L也明显低于对照组(46.2±9.8)ng/L,差异有统计学意义(t=5.979,P<0.01);同时,实验小鼠静脉血人类白细胞抗原DR(20.2±1.3)和协同刺激分子CD86的表达水平(36.8±13.5)明显高于对照组(11.6±1.5)和(26.7±8.5),差异有统计学意义(t=23.301和3.314,均P<0.01)。结论:DC可能通过诱导Th1/Th2细胞分化在变应性鼻炎实验小鼠发作时起重要作用,其可能的机制系通过DC分泌的细胞因子而起作用。
Objective: To investigate the possible role and mechanism of dendritic cells (DCs) in the pathogenesis of allergic rhinitis in experimental mice. Methods: CpGoligodeoxynucleotide (CpGODN1826) was used to induce DCs induced by allergic rhinitis in mice, and then the expression of DC costimulatory molecules CD80 and CD86 and the levels of IL10 and IL12 secreted by them were detected. Results: The level of IL-10 secreted by venous blood of experimental mice was significantly lower than that of the control group (3.6 ± 0.5) μg / L (6.8 ± 0.8) μg / L (t = 20.608, P <0.01) The level of IL12 was significantly lower than that of the control group (29.5 ± 6.4 ng / L, 46.2 ± 9.8 ng / L, t = 5.979, P <0.01). Meanwhile, the level of IL- The expression level of DR (20.2 ± 1.3) and costimulatory molecule CD86 (36.8 ± 13.5) was significantly higher than that of the control group (11.6 ± 1.5) and (26.7 ± 8.5) respectively (t = 23.301 and 3.314, both P <0.01). CONCLUSION: DC may play an important role in the pathogenesis of allergic rhinitis mice by inducing the differentiation of Th1 / Th2 cells. The possible mechanism is through the cytokines secreted by DCs.