结节性硬化 (ＴＳ)又称Ｂｏｕｒｎｅｖｉｌｌｅ病 ,是一种少见的常染色体显性遗传病。临床表现差异很大 ,大部分病例为散发 ,易漏诊误诊。本文对 12例ＴＳ患者临床表现结合有关文献进行分析 ,以提高对本病的认识和诊断水平。1　临床资料1 1　一般资料　本组 12例患者均来自门诊 Tuberous sclerosis (TS), also known as Bourneville disease, is a rare autosomal dominant disease. Very different clinical manifestations, most cases were disseminated, misdiagnosis of missed diagnosis. In this paper, 12 cases of TS patients with clinical manifestations of the relevant literature analysis to improve the understanding of the disease and the level of diagnosis. 1 Clinical data 1 1 General information The group of 12 patients were from the clinic