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目的 :探讨CD4 4在人喉癌组织中的表达及其临床意义。方法 :采用免疫组织化学Envision法对 2 61例喉不同病变组织标本进行CD4 4表达检测。结果 :人喉癌组织中CD4 4高表达率为 70 .9% ,明显高于癌前病变( 16.7% )及正常喉组织 ( 0 % ) ,其差异均有极显著性意义 (P <0 .0 1) ;喉癌组织中高分化鳞癌CD4 4表达明显低于低分化鳞癌 ( P <0 .0 1) ;Ⅲ～Ⅳ期喉癌病变组织CD4 4表达明显高于Ⅰ～Ⅱ期 ( P <0 .0 1) ;有颈淋巴结转移的喉癌组织CD4 4表达明显高于无颈淋巴结转移的喉癌组织 (P <0 .0 1) ;CD4 4表达阳性病例 3、5年生存率明显低于CD4 4表达阴性病例 (均 P <0 .0 5 )。结论 :喉癌的发生、发展及患者预后与CD4 4表达密切相关
Objective: To investigate the expression of CD4 4 in human laryngeal carcinoma and its clinical significance. Methods: Immunohistochemical Envision method was used to detect the expression of CD4 4 in 2161 cases of different pathological changes. Results: The high expression rate of CD4 4 in human laryngeal squamous cell carcinoma was 70.9%, which was significantly higher than that in precancerous lesions (16.7%) and normal laryngeal tissues (0%). The difference was significant (P <0. The expression of CD4 4 in well-differentiated squamous cell carcinoma was significantly lower than that in poorly differentiated squamous cell carcinoma (P <0.01). The expression of CD4 4 in stage Ⅲ-Ⅳ laryngeal carcinoma was significantly higher than that in stage Ⅰ-Ⅱ <0.01). The expression of CD4 4 in laryngeal carcinoma with cervical lymph node metastasis was significantly higher than that in laryngeal carcinoma without cervical lymph node metastasis (P0.01). The 3 and 5-year survival rate of CD4 + Lower than the negative cases of CD4 4 expression (all P <0.05). Conclusion: The occurrence and development of laryngeal cancer and the prognosis of patients are closely related to the expression of CD4