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在25±0.1℃,I=0.1mol·l~(-1)KNO_3条件下,在80%(V/V)DMSO—H_2O混合溶剂中,应用pH法测定了DL—苯丙氨酸、甘氨酸、L—缬氨酸、L—丝氨酸、L—异亮氨酸、L—脯氨酸等α—氨基酸的电离常数;铜(Ⅱ)—α—氨基酸二元配合物和铜(Ⅲ)—芬布芬—α—氨基酸三元配合物的稳定常数。使用的α—氨基酸均为生化试剂。实验发现,在Logβ_(102)与pK_b~B,logβ_(111)与pK_2~B及logβ_(111)与olgβ_(102)三对参数之间均存在良好的直线自由能关系。用ΔlogK和Δlogβ_(111)表征了三元混配型配合物相对于二元母体配合物的稳定性.讨论了溶剂的性质、配体之间的堆积作用和疏水作用对配合物稳定性的影响。
Under the conditions of 25 ± 0.1 ℃, I = 0.1mol·L ~ (-1) KNO_3 in the mixed solvent of 80% (V / V) DMSO-H_2O, the contents of DL- phenylalanine, Ionization constants of α-amino acids such as L-valine, L-serine, L-isoleucine and L-proline; copper (II) -alpha- amino acid binary complexes and copper (III) Finn-a-amino acid ternary complex stability constants. The α-amino acids used are biochemical reagents. Experiments showed that there was a good linear free energy relationship between Logβ 102 and pK_b B, log β 111 and pK 2 B, and log β 111 and olg β 102. The stability of the ternary complex with respect to the binary parent complex was characterized by ΔlogK and Δlogβ_ (111). The effects of the solvent, the stacking between ligands and the hydrophobicity on the stability of the complex were discussed .