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为探讨ＭＥＥ细胞与腭裂发生的关系，对１８４例ＮＩＨ胎鼠腭器官发生期不同阶段的头颅标本进行了组织胚胎学研究。结果表明，两组ＭＥＥ细胞于胎龄１４（１８）ｄ（ｈ）的标本中开始出现差异，正常组ＭＥＥ细胞逐渐由二层变为一层；给药组ＭＥＥ细胞有３种存在形式：①二层细胞；②假复层纤毛柱状上皮；③复层扁平鳞状上皮。１５（０）～１６（１８）ｄ（ｈ），正常组两腭突基底层ＭＥＥ细胞逐渐接触融合，最后中胚层组织也接触融合，ＭＥＥ细胞消失；给药组的腭裂标本ＭＥＥ细胞转归为口腔上皮。证明ＭＥＥ细胞的异常转归可导致腭裂畸形
In order to investigate the relationship between MEE cells and the cleft palate, we studied the embryonic development of 184 skull specimens from different stages of palatal organ development in NIH fetuses. The results showed that MEE cells in two groups began to show differences in the 14 (18) d (h) gestational age, and MEE cells in the normal group gradually changed from two layers to one layer. There were three existing forms of MEE cells in the administration group: ① Two layers of cells; ② pseudostratified ciliated columnar epithelium; ③ stratified squamous squamous epithelium. The MEE cells in the basal layer of the palatal base of the normal group gradually contacted with the fusion, and finally the mesoderm tissues also contacted with the fusion and the MEE cells disappeared. The MEE cells of the cleft palate specimens in the administration group were (15 (0) ~16 (18) d Oral epithelium. Proved abnormal MEE cells can lead to cleft palate deformities