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目的 比较中国人与日本人初诊2型糖尿病(T2DM)患者胰岛素抵抗(IR)的特征及相关因素的异同。 方法 应用由日本国立京都病院国家糖尿病研究中心设计的登录系统文件,对确诊的T2DM进行登录,计中国人 1578 例(中国人组),日本人 1813 例(日本人组)。用 HOMA IR评价IR,评价单纯性糖尿病者、糖尿病伴高血压者、糖尿病伴脂代谢紊乱者及糖尿病伴高血压和脂代谢紊乱者 IR的异同,并将两组进行比较。 结果 在中国人组与日本人组随着糖尿病伴有高血压、脂代谢紊乱及伴有高血压和脂代谢紊乱的叠加,空腹胰岛素(FIns)值增加,HOMA IR值增大。中国人各组的FIns、HOMA IR值与日本人相应组比较差异均有统计学意义(P<0.01)。体质指数(BMI)中国人组明显高于日本人组(t=2 61,P<0.01),患高血压、脂代谢紊乱的百分比中国人组比日本人组高(t=3.57、4.64, P<0.01)。以IR为因变量,以年龄、吸烟、饮酒、BMI、空腹血糖(FPG)、2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、高血压、脂代谢紊乱为自变量,进行广义线形模型分析,结果显示:中国人组IR与高血压、脂代谢紊乱有关(OR=1.384、1.253,P=0 0011、0.0049),日本人组IR与BMI、高血压有关(OR= 1.062、1.340, P< 0.0001、P= 0.0182)。 结论 在初诊的 T2DM 患者, IR 与BMI、高血压、脂代谢?
Objective To compare the characteristics of insulin resistance (IR) between Chinese and Japanese newly diagnosed type 2 diabetic patients (T2DM) and the related factors. Methods The registration system designed by National Diabetes Research Center of Kyoto National Hospital of Japan was used to log in T2DM patients with 1578 cases of Chinese (Chinese group) and 1813 Japanese (Japanese group). HOMA IR was used to evaluate the IR, and to evaluate the differences of IR among those with simple diabetes mellitus, patients with diabetes mellitus, diabetes mellitus with lipid metabolism, and diabetes mellitus with hypertension and dyslipidemia. The two groups were compared. Results In the Chinese and Japanese groups, with the increase of FIns and the increase of HOMA IR, diabetes complicated with hypertension, dyslipidemia and superposition of hypertension and dyslipidemia. The FIns and HOMA IR values in Chinese groups were significantly different from those in Japanese corresponding groups (P <0.01). The body mass index (BMI) in Chinese group was significantly higher than that in Japanese group (t = 2161, P <0.01). The percentage of hypertension and lipid disorders was higher in Chinese group than in Japanese group (t = 3.57,4.64, P <0.01). Using IR as the dependent variable, the generalized linear model was analyzed with age, smoking, alcohol consumption, BMI, FPG, 2hPG, HbAlc, hypertension and dyslipidemia as independent variables. The results showed that IR was associated with hypertension and dyslipidemia (OR = 1.384, 1.243, P = 0.0011, 0.0049) in Chinese subjects. IR was associated with BMI and hypertension (OR = 1.062,1.340, P <0.0001) , P = 0.0182). Conclusions In newly diagnosed T2DM patients, IR and BMI, hypertension, lipid metabolism?