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目的 :研究 p16在卵巢肿瘤中的表达及意义。 方法 :应用免疫组化ABC法检测 133例卵巢肿瘤和 12例正常卵巢组织 p16的表达。 结果 :卵巢肿瘤与正常卵巢组织 p16表达有显著性差异。正常卵巢没有 p16表达的缺失 ,良性、交界性、恶性组p16表达明显下降 (P <0 .0 5 )。上皮性组晚期、残存癌灶≥ 2cm者 p16表达明显低于早期、残存癌灶 <2cm者 (P <0 .0 5 ) ;p16表达与组织类型、组织分化、淋巴结转移无关 (P >0 .0 5 )。生存分析表明p16尚不能作为卵巢癌的独立预后因素。结论 :p16蛋白在卵巢肿瘤中存在不同程度的缺失 ,与卵巢癌的发生、发展有一定关系。p16能否作为卵巢癌的预后指标尚需进一步研究。
Objective: To study the expression and significance of p16 in ovarian tumors. Methods: Immunohistochemical ABC method was used to detect the expression of p16 in 133 cases of ovarian tumors and 12 cases of normal ovarian tissues. Results: There was a significant difference in p16 expression between ovarian tumors and normal ovarian tissues. There was no deletion of p16 in normal ovary, and the expression of p16 was significantly decreased in benign, borderline and malignant groups (P <0.05). The expression of p16 was significantly lower in patients with epithelia than in those with early or late cancers ≥ 2 cm (P <0.05). The expression of p16 was not associated with histological type, histological differentiation and lymph node metastasis (P> 0.05). 0 5). Survival analysis shows that p16 is not yet an independent prognostic factor for ovarian cancer. Conclusion: There is a certain degree of deletion of p16 protein in ovarian tumors, which is related to the occurrence and development of ovarian cancer. Whether p16 can be used as a prognostic indicator of ovarian cancer needs further study.