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目的:探讨郁星菖志汤联合盐酸丁罗环酮治疗脑卒中后抑郁症的疗效。方法:收集2013年9月~2016年2月我院收治的60例脑卒中后抑郁症患者为研究对象,随机数字表法均分为联合组及对照组各30例,2组均实施盐酸丁罗环酮治疗,联合组另给予郁星菖志汤治疗,观察治疗前后2组抑郁及神经功能相关指标[汉密尔顿抑郁量表(HAMD)评分、改良爱丁堡斯堪的纳维亚神经卒中量表(SNSS)评分]、中医临床疗效、日常生活能力量表(ADL)评分变化及药物安全性。结果:治疗前2组HAMD评分、SNSS评分、ADL量表评分相较无明显差异(P>0.05);治疗后2组HAMD评分、ADL评分较治疗前明显降低,SNSS评分明显升高,且治疗后联合组HAMD评分、ADL评分较对照组降低明显,SNSS评分升高明显,有统计学意义(P<0.05);治疗后联合组中医临床总有效率83.33%、不良反应总发生率6.67%较对照组明显高、低,差异显著(P<0.05)。结论:郁星菖志汤联合盐酸丁罗环酮有效降低患者HAMD、ADL评分,升高SNSS评分,提高中医临床疗效,是一种疗效确切、安全可靠的药物方案。
Objective: To investigate the curative effect of Yu Xing Chang Zhi Tang combined with buprenorphine hydrochloride on post-stroke depression. Methods: Sixty patients with post-stroke depression who were admitted to our hospital from September 2013 to February 2016 were selected as study subjects. Random number table was divided into 30 cases in each group and 30 cases in control group. Loraldone treatment, the combination group was given Yu Xing Chang Zhi Tang treatment, observed before and after treatment two groups of indicators of depression and neurological function [Hamilton Depression Scale (HAMD) score, improve the Scandinavian Nerve Stroke Scale [ SNSS score], clinical curative effect of TCM, change of ADL score and drug safety. Results: The scores of HAMD, SNSS and ADL in the two groups before treatment had no significant difference (P> 0.05). The scores of HAMD and ADL in the two groups after treatment were significantly lower than those before treatment and SNSS scores were significantly increased The post-combination HAMD score and ADL score decreased significantly compared with the control group, and the SNSS score increased significantly (P <0.05). After treatment, the total clinical effective rate was 83.33% and the total adverse reaction rate was 6.67% The control group was significantly higher and lower, the difference was significant (P <0.05). Conclusion: Yuxing Changzhi Decoction combined with buprenorphine hydrochloride can effectively reduce the HAMD and ADL score, increase the SNSS score and improve the clinical curative effect of TCM. It is an effective and safe drug program.