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目的探讨玻璃化冷冻技术在人类早期胚胎冻存中的临床应用价值。方法回顾性分析本中心822个冷冻胚胎复苏周期,依据胚胎冷冻方法的不同分为玻璃化冷冻组(490个周期)和程序化冷冻组(332个周期),比较两组胚胎复苏率、复苏胚胎完整率、胚胎种植率、临床妊娠率等数据。结果玻璃化冷冻复苏组与程序化冷冻复苏组胚胎复苏率分别为98.8%和82.9%,复苏胚胎完整率分别为96.8%和63.1%,胚胎种植率分别为32.0%和18.1%,临床妊娠率分别为53.9%和33.1%,两组数据比较差异均有统计学意义(P<0.05)。结论玻璃化冷冻法比程序化冷冻法更适合于人类早期胚胎的冷冻保存。
Objective To investigate the clinical value of vitrification in cryopreservation of human early embryos. Methods Retrospective analysis of 822 frozen embryos resuscitation cycles in our center was divided into vitrification group (490 cycles) and programmed freezing group (332 cycles) according to embryo freezing method. The embryo recovery rate, embryo resuscitation Complete rate, embryo implantation rate, clinical pregnancy rate and other data. Results The rates of embryo resuscitation were 98.8% and 82.9% in the vitrification and programmed cryosurgery groups, respectively. The rates of complete embryo resuscitation were 96.8% and 63.1%, respectively. The embryo implantation rates were 32.0% and 18.1% Was 53.9% and 33.1% respectively. There was significant difference between the two groups (P <0.05). Conclusion Vitrification is more suitable for cryopreservation of human early embryos than programmed freezing.