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目的 探讨 5 氟尿嘧啶 (5 Fu)持续 48小时静脉灌注治疗头颈癌及消化道恶性肿瘤的近期疗效及毒副反应。方法 设实验组和对照组各 3 0例进行对比研究 ,实验组采用甲酰四氢叶酸钙 (CF) 3 0 0mg/m2 静滴 + 5 氟尿嘧啶 (5 Fu) 0 .5g静推后 ,再用 5 Fu 4.5 g持续 48小时静脉灌注 ,在整个灌注过程中每 6小时口服安曲希片 (甲酰四氢叶酸钙片 )75mg ,共 7次 ,对照组仍以常规甲酰四氢叶酸钙 3 0 0mg/m2 静滴 + 5 Fu 0 .5 g连续 5天静脉推注 ,两组头颈癌病例同时使用卡铂 (CBP) 3 0 0mg/m2 联合用药 ,全部病例均接受 4个疗程以上的化疗。结果 实验组CR 1例 ,PR 9例 ,NC 15例 ,PD 5例 ,总有效率为 3 3 .3 3 % ;对照组PR 7例 ,NC 13例 ,PD 10例 ,有效率为 2 3 .3 3 %。两组病例主要毒副反应为外周静脉炎、口腔粘膜炎、恶心、呕吐、腹痛、腹泻等。实验组Ⅲ～Ⅳ度外周静脉炎占 43 .0 4% ,对照组较实验组低为 2 9.65 %(P >0 .0 5 )。相反 ,实验组消化道反应发生率明显低于对照组 ,分别为 1.5 2 %和 2 6.83 % (P <0 .0 5 )。因反应使疗程延期者 ,对照组也明显高于实验组。结论 5 Fu持续 48小时静脉灌注治疗头颈部及消化道恶性肿瘤的近期疗效优于常规 5天疗法 ,且毒副反应小 ,值得临床推广使用。
Objective To investigate the short-term curative effect and side effects of intravenous infusion of 5-fluorouracil (5 Fu) for 48 hours in patients with head and neck cancer and gastrointestinal cancer. Methods The experimental group and the control group of 30 cases of comparative study, the experimental group with leucovorin (CF) 300 mg / m2 intravenous infusion of 5 Fu (5 Fu) 0. 5g after the re-use 5 Fu 4.5 g for 48 hours intravenous infusion of oral Anjax tablets (leucovorin tablets) 75mg every 6 hours, a total of 7 times, the control group is still conventional leucovorin 3 0 0mg / m2 intravenous infusion of 5 Fu 0.5 g 5 consecutive days of intravenous injection, both cases of head and neck cancer with carboplatin (CBP) 300 mg / m2 combination therapy, all patients received more than 4 courses of chemotherapy . Results In the experimental group, CR was 1, PR 9, NC 15, and PD 5, with a total effective rate of 33.33%. In the control group, PR 7, NC 13 and PD 10, the effective rate was 23. 3 3%. The two groups of patients with major side effects of phlebitis, oral mucositis, nausea, vomiting, abdominal pain, diarrhea and so on. The experimental group Ⅲ ~ Ⅳ peripheral phlebitis accounted for 43.04%, the control group was lower than the experimental group 2 9.65% (P> 0.05). In contrast, the incidence of digestive tract reactions in the experimental group was significantly lower than those in the control group, 1.5 2% and 2 6.83%, respectively (P <0.05). Due to the reaction delay treatment, the control group was significantly higher than the experimental group. Conclusion 5 Fu for 48 hours continuous intravenous infusion of head and neck and digestive tract cancer treatment is better than conventional 5 days treatment, and the side effects of small, worthy of clinical promotion and use.