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目的:探讨微剂量肝素联合冷沉淀治疗新生儿弥散性血管内凝血的疗效。方法:选我院2010年至2012年共61例确诊为新生儿弥散性血管内凝血病例,在积极治疗原发病的同时,给予微剂量肝素皮下注射及联合输注冷沉淀治疗。结果:58例于用药后48小时内凝血功能恢复正常,血小板于平均于4天内恢复正常,1例死亡,2例因病情重家属放弃抢救并出院,总有效率95.1%,在用药前后比差异具有统计学意义(P<0.05)。结论:微剂量肝素联合冷沉淀治疗弥散性血管内凝血安全有效。
Objective: To investigate the effect of micro-dose heparin combined with cryoprecipitation in the treatment of diffuse intravascular coagulation in neonates. Methods: A total of 61 cases diagnosed as neonatal disseminated intravascular coagulation in our hospital from 2010 to 2012 were treated with subcutaneous injection of micro-dose of heparin and cold infusion in conjunction with infusion therapy while actively treating the primary disease. Results: In 58 cases, the coagulation function returned to normal within 48 hours after treatment. Platelet returned to normal within 4 days, 1 died, and 2 patients were given resuscitation and discharged due to serious illness. The total effective rate was 95.1%, before and after treatment Statistically significant (P <0.05). Conclusion: Dose of heparin combined with cryoprecipitate in the treatment of disseminated intravascular coagulation is safe and effective.