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目的探讨布地奈德和沙丁胺醇治疗慢性喘息性支气管炎的疗效及与患儿血清sIgE水平的关系。方法检测80例慢性喘息性支气管炎患儿血清IgE水平,并根据血清sIgE水平,分为sIgE阳性组和sIgE阴性组,两组患儿均给予布地奈德和沙丁胺醇治疗,观察两组临床疗效。结果 sIgE阳性组临床总有效率达88.89%,显著高于sIgE阴性组,组间差异有统计学意义(P<0.05),sIgE阳性组肺部干音、湿音、咳嗽和喘憋消失时间均短于sIgE阴性组,差异有统计学意义(P<0.05)。结论慢性喘息性支气管炎患儿血清sIgE阳性者对激素和沙丁胺醇的疗效更为敏感,喘息症状缓解得更快,监测患儿血清sIgE水平有助于预测临床治疗效果和预后。
Objective To investigate the curative effect of budesonide and salbutamol on chronic asthmatic bronchitis and its relationship with sIgE level in children. Methods Serum IgE levels were measured in 80 children with chronic asthmatic bronchitis and divided into sIgE-positive and sIgE-negative groups according to serum sIgE levels. Both groups were given budesonide and salbutamol for treatment, and the clinical efficacy was observed. Results The total clinical effective rate of sIgE positive group was 88.89%, which was significantly higher than that of sIgE negative group (P <0.05). The time of lung dryness, wet sound, cough and wheezing disappearance in sIgE positive group Shorter than sIgE negative group, the difference was statistically significant (P <0.05). Conclusion Serum sIgE-positive children with chronic asthmatic bronchitis are more sensitive to the effects of hormones and salbutamol, and the symptoms of wheezing are relieved more quickly. Monitoring serum sIgE level in children with asthmatic bronchitis will be helpful to predict the clinical effect and prognosis.