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研究水了化硅酸三钙(Ca3SiO5,C3S)固化体的体外生物活性行为。结果表明,干C3S固化体中含有23.97wt%的Ca(OH)2,Ca(OH)2的溶解导致模拟体液(Simulated Body Fluids,SBF)的pH值上升;磷灰石颗粒优先诱导沉积于C3S固化体表面,随后碳酸钙和磷灰石颗粒共同沉积于C3S固化体表面;HCO3-是SBF模拟体液内主要的缓冲离子;Ca(OH)2碳化和CaCO3沉积主要导致SBF的pH值下降。由于离子交换作用的减弱,C3S固化体表面最终被磷灰石完全覆盖,磷灰石的沉积促使SBF的pH值进一步降低。因此,对于C3S和其衍生材料的体外生物活性和生物相容性必须考虑到HCO3-在体内的实际含量和行为。
The in vitro biological activity of water-cured tricalcium silicate (Ca3SiO5, C3S) was studied. The results showed that Ca (OH) 2 contained 23.97wt% Ca (OH) 2 in dry C3S solid solution, and the pH value of Simulated Body Fluids (SBF) increased due to the dissolution of Ca (OH) The surface of the solidified body was then precipitated with calcium carbonate and apatite particles on the surface of C3S solidified body. HCO3- was the main buffer ion in SBF simulated body fluid. The carbonation of Ca (OH) 2 and the deposition of CaCO3 mainly resulted in the decrease of pH of SBF. Due to the weakening of ion exchange, the surface of C3S solidified body was completely covered by apatite, and the sedimentation of apatite further reduced the pH value of SBF. Therefore, in vitro bioactivity and biocompatibility of C3S and its derivatives must take into account the actual content and behavior of HCO3- in the body.