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目的探讨TNP1基因单核苷酸多态性(single nucleotide polymorphism,SNP)与中国四川地区男性不育的相关性。方法应用DNA测序技术分别对325例男性不育患者(包括166例非梗阻性无精子症和159例少精子症,病例组)和194例已生育的男性人群(对照组)TNP1基因的3个SNP位点(rs1179733、rs1179734、rs1179735)进行检测。分析比较基因型、等位基因及单体型频率在患者组和对照组中的分布特点。结果 TNP1基因的3个多态性位点的基因型及等位基因频率在病例组与对照组间无显著性差异(P>0.05),进一步进行单体型分析,其频率分布在两组中也无显著性差异(P>0.05)。结论 TNP1基因rs1179733、rs1179734、rs1179735多态性与四川地区男性不育无相关性。
Objective To investigate the association between single nucleotide polymorphism (SNP) of TNP1 gene and male infertility in Sichuan, China. Methods Three hundred and twenty-five male infertile patients (including 166 cases of non-obstructive azoospermia and 159 cases of oligospermia and case group) and TNM1 gene of 194 infertile men (control group) were detected by DNA sequencing. SNP sites (rs1179733, rs1179734, rs1179735) were tested. Analysis of genotypes, alleles and haplotype frequencies in patients and control group distribution characteristics. Results There was no significant difference in the genotypes and allele frequencies of the three polymorphic loci in TNP1 gene between the case group and the control group (P> 0.05). The frequency of TNP1 gene polymorphism was also analyzed in two groups There was no significant difference (P> 0.05). Conclusion The polymorphisms of rs1179733, rs1179734 and rs1179735 of TNP1 gene have no correlation with male infertility in Sichuan Province.