测定体液中药物的含量往往由于样品中高分子蛋白质易在色谱柱中析出,导致柱效下降。通常药物在进样前都需经提取浓缩。这些步骤不仅费时费力,而且增加了分析误差。HPLC柱切换是一种广泛应用的自动进行样品净化和待测物浓缩的技术。该技术是先将样品直接注入预柱, Determining the amount of drug in the body fluid is often due to the sample of polymer protein precipitation in the column, resulting in decreased efficiency. Drugs are usually concentrated before extraction. These steps not only time-consuming and labor-intensive, but also increase the error analysis. HPLC column switching is a widely used technique for automated sample cleanup and sample concentration. The technology is the first sample directly into the pre-column,