细胞角蛋白(Cytokeratin)是上皮细胞中间丝的成分,依上皮类型和分化程度不同而表达不同亚型:角蛋白-20(CK-20)是这一家族的成员,于1990年发现,分子量为48 533 u。最近用逆转录-聚合酶链反应(RT-PCR)方法证明在正常血细胞中无CK-20转录,子宫内膜良性疾病不表达CK-20,而内膜癌时则呈阳性。为探讨检测血中CK-20用于检出子宫内膜癌患者血循环中恶性细胞的可行性,对59例经病理证 Cytokeratin is a component of epithelial mesangial cells that express different subtypes depending on epithelial type and degree of differentiation: Keratin-20 (CK-20) is a member of this family and was found in 1990 to have a molecular weight of 48 533 u. Recent studies using reverse transcription-polymerase chain reaction (RT-PCR) demonstrated no CK-20 transcription in normal blood cells, benign endometrial disease did not express CK-20, and endometrial cancer was positive. To investigate the detection of blood CK-20 for the detection of malignant cells in the blood circulation of patients with endometrial cancer, 59 cases of pathological evidence