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目的探讨急性冠脉综合征(ACS)患者高敏C-反应蛋白(hs-CRP)与血清尿酸(UA)的变化及临床意义。方法选择临床及冠状动脉造影明确诊断的急性冠脉综合征患者82例[其中急性心肌梗死(AMI)34例,不稳定型心绞痛(UAP)48例],为ACS组,另选冠状动脉造影正常者30例为对照组,分别测定两组hs-CRP、UA,并进行比较。结果AMI、UAP组hs-CRP较对照组明显增高(P<0.01),AMI、UAP组UA较对照组明显增高(P<0.05)。结论hs-CRP水平与血清UA水平升高和ACS关系密切,可作为冠心病危险的预测因子。
Objective To investigate the changes and clinical significance of high sensitivity C-reactive protein (hs-CRP) and serum uric acid (UA) in patients with acute coronary syndrome (ACS). Methods A total of 82 patients with acute coronary syndrome (including 34 patients with acute myocardial infarction (AMI) and 48 patients with unstable angina pectoris (UAP)) were enrolled in this study. They were ACS patients with normal coronary angiography 30 patients as control group, respectively, two groups were measured hs-CRP, UA, and compared. Results The hs-CRP in AMI and UAP group was significantly higher than that in control group (P <0.01). The UA in AMI group and UAP group was significantly higher than that in control group (P <0.05). Conclusion The level of hs-CRP is closely related to the increase of serum UA level and ACS, which can be used as a predictor of coronary heart disease risk.