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复方新诺明是治疗尿路感染和呼吸道感染的常用药物。但近一年多来,不断发现复方新诺明药物过敏的病例,据北京宣武医院统计,该院每月平均有10余例。其过敏反应轻者出现红斑性药疹,重者则发生大疱性表皮松解萎缩坏死性或剥脱性皮炎,甚至危及患者生命。如某男性患者64岁,因左下肢骨折合并肺部感染,服用复方新诺明2～3月后出现皮疹,以激素治疗后稍减轻,又服磺胺增效剂(TMP)后皮疹加重,遍及全身,进展迅猛,呈全身表皮剥脱,经多种措施抢救无效死亡。某女性患者21岁,因扁桃体炎发烧,服复方新诺明,2日后仍发烧不退,上肢躯干出
Cotrimoxazole is a commonly used drug for the treatment of urinary tract infections and respiratory infections. However, over the past year and more, we have continuously found cases of cotrimoxazole allergy. According to the statistics of Beijing Xuanwu Hospital, the hospital has an average of more than 10 cases every month. The allergic reaction of erythema drug eruption appears light, severe cases of epidermolysis bullosa atrophy necrosis or exfoliative dermatitis, and even endanger the lives of patients. If a male patient 64 years old, due to left lower extremity fracture with pulmonary infection, taking compound norepinephrosin 2 to 3 months after the rash to a slight reduction after hormone therapy, and sulfamethoxazole synergist (TMP) after the rash, over The whole body, rapid progress, was the whole body epidermis, died after a variety of measures to rescue ineffective. A 21-year-old female patient suffered from fever due to tonsillitis and cotrimoxazole, fever after 2 days,