类胰蛋白酶是与胰蛋白酶有关的另一类丝氨酸蛋白酶 ,主要由肥大细胞表达和储存。由于类胰蛋白酶具有四聚体晶体的特殊结构 ,其生化和生物学特征与胰蛋白酶及其他蛋白酶家族又有所区别。类胰蛋白酶通过形成四聚体 ,在组织中获得酶活性 ,并通过裂解一些关键蛋白、活化一些具有广泛特异性的蛋白酶、刺激细胞反应 ,导致气道高反应、慢性气道炎症和气道重建 ,在支气管哮喘发病过程中起重要作用。 Tryptase is another tryptase-related serine protease, mainly expressed and stored by mast cells. Because tryptase has a special structure of tetrameric crystals, its biochemical and biological characteristics are different from that of trypsin and other protease families. Trypsin, through the formation of tetramers, gains enzyme activity in tissues and activates a number of proteases with broad specificity by cleaving some key proteins, stimulating cellular responses, leading to airway hyperresponsiveness, chronic airway inflammation and airway remodeling, Plays an important role in the pathogenesis of bronchial asthma.