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芸香甙(Ru)是黄酮类化合物,本文就其抗氧化作用进行研究。在兔RBC体外温育自氧化试验中,3.2×10-5mol·L-1Ru可显著抑制RBC自氧化.并可减少RBC自氧化过程中脂质过氧化产物──MDA的含量.说明RU对RBC的自氧化溶血损伤有一定的保护作用,并可能与抑制脂质过氧化反应有关;灌胃Ru20~80mg·kg-1不仅可显著减少小鼠血浆中MDA含量,也可显著提高大鼠血浆中SOD活性,并有一定的量效关系,结果进一步提示RU抗脂质过氧化作用可能与提高SOD活性有关。
Rutin (Ru) is a flavonoid compounds, the antioxidant effect of this study. In rabbit RBC self-oxidation incubation test in vitro, 3.2 × 10-5mol·L-1Ru significantly inhibited RBC autoxidation. And reduce the RBC auto-oxidation of lipid peroxidation products ─ ─ MDA content. This indicated that RU could protect RBC from auto-oxidative hemolysis and may be related to the inhibition of lipid peroxidation. Administration of Ru20-80mg · kg-1 could not only significantly reduce the content of MDA in mice plasma, but also significantly increase Rat plasma SOD activity, and a certain dose-effect relationship, the results further suggest that RU anti-lipid peroxidation may be related to increasing SOD activity.