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目的本研究探讨用胰岛素治疗但未受过降脂治疗的成人I型糖尿病患者ApoB水平和糖化血红蛋白等指标的关系。方法 72例1型糖尿病血液样本用常规生化方法检测患者肌酐(Cr),总胆固醇(TC),甘油三脂(TG),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),总胆固醇与高密度脂蛋白胆固醇比值TC/HDL-C的比值和载脂蛋白B(ApoB)、免疫比浊法检测载脂蛋白B(ApoB),色谱法检测糖化血红蛋白(HbA1c)。结果 ApoB、LDL-C、TC与糖化血红蛋白没有显著相关性,TG与糖化血红蛋白显著相关性(P<0.05)。2个患者(2.7%)LDL-C升高,3个患者(4.1%)TG升高,4个患者(5.5%)HDL-C较低,8个患者(11.1%)TC/HDL-C比值(>4.0)偏高。女性HDL-C水平显著高于男性(P<0.001),TC/HDL-C比值女性明显低于男性(P<0.001)。结论未接受降脂治疗的1型糖尿病患ApoB均值增高比例较低。糖化血红蛋白和心血管疾病危险因子如LDL-C,ApoB没有显著相关性。脂质表型的差异对临床降脂治疗有不同效果。
Objective To investigate the relationship between ApoB levels and HbA1c in adults with type 1 diabetes treated with insulin but not lipid-lowering therapy. Methods Serum creatinine (Cr), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL) were measured in 72 patients with type 1 diabetes mellitus C), ratio of total cholesterol to high-density lipoprotein cholesterol (TC / HDL-C), apolipoprotein B (ApoB), ApoB by immunoturbidimetry, HbA1c by chromatography, . Results There was no significant correlation between ApoB, LDL-C, TC and glycosylated hemoglobin, TG and glycosylated hemoglobin (P <0.05). HDL-C was elevated in 2 patients (2.7%), elevated TG in 3 patients (4.1%), low HDL-C in 4 patients (5.5%) and TC / HDL-C ratio in 8 patients (> 4.0) high. Female HDL-C levels were significantly higher than male (P <0.001), TC / HDL-C ratio was significantly lower in women than men (P <0.001). Conclusions ApoB patients with type 1 diabetes who did not receive lipid-lowering therapy had a lower mean increase in ApoB. Glycated hemoglobin and cardiovascular risk factors such as LDL-C, ApoB no significant correlation. Differences in lipid phenotypes have different effects on clinical lipid-lowering therapy.