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目的 :了解江苏省某地区既往有偿献血人员丙型肝炎病毒(hepatits C virus,HCV)的感染情况并探讨其危险因素。方法:对该地区部分有既往有偿献血史的村民进行问卷调查和肝脏B超检查,并采集静脉血进行相关生化检测。应用Epi Data和SPSS软件对数据进行录入及统计学分析。结果:781名调查对象共检测出抗-HCV抗体阳性510例,感染率为65.3%,抗体阳性者中持续感染者占70.6%(360/510),自限清除者占29.4%(150/510)。HCV持续感染者以1b+3混合型(51.7%)和1b型(32.9%)为主。持续感染组丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、谷氨酰转移酶(GGT)的异常率高于未感染组和自限清除组。多因素Logistic回归分析显示性别、献全血史和单采血浆史是既往有偿献血人群感染HCV的危险因素,OR值分别为1.50、2.27和3.27;年龄是HCV感染慢性化的危险因素,OR值为1.62。结论 :既往有偿献血人群的HCV感染率处于较高水平,不洁采供血特别是单采血浆可能是导致HCV高感染率的主要原因。
Objective: To investigate the prevalence of hepatitis C virus (HCV) among paid blood donors in a certain area of Jiangsu Province and to explore its risk factors. Methods: Questionnaires and liver B-ultrasound were performed on some villagers who had previous history of blood donation in this area. Blood samples were collected for biochemical tests. Data entry and statistical analysis were performed using Epi Data and SPSS software. Results: Of the 781 respondents, 510 were positive for anti-HCV antibodies with a prevalence of 65.3%, persistent infections were 70.6% (360/510) and self-limited was 29.4% (150/510) ). The HCV co-infected patients were predominantly 1b + 3 mixed (51.7%) and 1b (32.9%). In the persistent infection group, the abnormal rates of ALT, AST and GGT were higher than those in the uninfected and self-limited groups. Multivariate logistic regression analysis showed that gender, blood donation history and plasma apheresis were the risk factors for HCV infection in previously paid blood donors, with odds ratios of 1.50, 2.27 and 3.27, respectively. Age was a risk factor for chronic HCV infection, and odds ratio was OR Is 1.62. CONCLUSIONS: The prevalence of HCV infection in previously paid blood donors is at a high level. Unclean blood collection, especially apheresis plasma, may be the main reason for the high infection rate of HCV.