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目的观察氟比洛芬酯对下腹部手术患儿超前镇痛的效果。方法拟行下腹部手术的患儿40例,随机分为氟比洛芬酯组(F组)和对照组(N组),每组20例。F组在手术开始前15min,将氟比洛芬酯1.25mg/kg用生理盐水稀释至20ml缓慢静脉注射;N组静脉注射等量的生理盐水。记录术后2、6、12、24h患儿VAS评分;观察并记录两组术后镇痛药应用次数及人数,及可能出现的不良反应,如嗜睡、恶心呕吐、呼吸抑制、异常出血、皮肤瘙痒等。结果与N组比较,F组术后2、6、12h时间点VAS评分明显降低(P<0.05),术后24h时VAS评分两组间比较差异无统计学意义(P>0.05);两组不良反应发生率的差异无统计学意义(P>0.05);F组术后镇痛药应用次数及术后用镇痛药人数明显少于N组(P<0.05)。结论氟比洛芬酯具有较强的超前镇痛作用,使手术镇痛维持时间延长,减少了术后其他镇痛药物的应用。
Objective To observe the effect of flurbiprofen axetil on preemptive analgesia in children undergoing abdominal surgery. Methods Forty children undergoing abdominal surgery were randomly divided into two groups: the flurbiprofen ester group (F group) and the control group (N group), with 20 cases in each group. F group before surgery 15min, flurbiprofen axetil 1.25mg / kg diluted with saline to 20ml slow intravenous injection; N intravenous injection of the same amount of saline. VAS scores were recorded at 2, 6, 12, and 24 hours after operation. The number and number of postoperative analgesics and the possible adverse reactions such as lethargy, nausea and vomiting, respiratory depression, abnormal bleeding, Itching and so on. Results Compared with N group, the VAS score of group F at 2, 6 and 12 h postoperatively was significantly lower (P <0.05), and there was no significant difference of VAS score between the two groups at 24 h postoperatively (P> 0.05) There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The number of postoperative analgesics and the number of postoperative analgesics in group F were significantly less than those in group N (P <0.05). Conclusion Flurbiprofen axetil has strong analgesic effect, prolonging the duration of analgesia and reducing the application of other analgesic drugs.