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目的 阐明大鼠双侧肾上腺切除后垂体前叶生长相关蛋白 43(GAP- 43)免疫阳性神经纤维表达的量与术后时间点的关系 ,即轴突发芽的时间过程 .方法 免疫组织化学ABC法 .结果 大鼠双侧肾上腺切除术后第 4日垂体前叶GAP- 43阳性表达显著增多 ,第 2周有所下降 ,至第 4周基本降至正常水平 .结论 大鼠在双侧肾上腺切除后 ,垂体前叶出现肽能神经纤维发芽 ,并围绕在腺细胞周围 ,该发芽过程于术后 4～ 7d达到高峰 ,第 2周开始下降 ,第 4周基本结束
Objective To elucidate the relationship between the expression of GAP-43 immunoreactive nerve fibers and the postoperative time point after bilateral adrenalectomy in rats, ie, the time course of axon sprouting.Methods Immunohistochemical ABC Method.Results The positive expression of GAP-43 in the anterior pituitary increased significantly on the 4th day after bilateral adrenalectomy in rats, decreased from the second week to the normal level in the fourth week.Conclusion The bilateral adrenalectomy After the pituitary appeared peptide nerve fibers sprouting and around the gland cells, the germination process peaked 4 ~ 7d after surgery, began to decline the second week, the fourth week basically ended