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报道了盐酸二氢埃托啡（ＤＨＥ）临床替代３８例海洛因成瘾者的替代抑制试验，并应用ＣＩＮＡ量表评价海洛因成瘾者的身体依赖性程度（１）。结果表明：盐酸二氢埃托啡可与那洛酮竞争阿片受体，对戒断症状的１００％替代抑制量与海洛因成瘾者的身体依赖性强度呈正相关，剂量反应关系良好。本研究同时对啡盐酸二氢埃托啡的身体依赖性潜力进行了讨论（３，７）。
An alternative suppressive trial of DHE as a clinical alternative to 38 heroin addicts was reported and the degree of physical dependence of heroin addicts was assessed using the CINA scale (1). The results showed that dihydroetorphine hydrochloride could compete with naloxone for opioid receptors, and the 100% substitution inhibition of withdrawal symptoms was positively correlated with the body-dependent intensity of heroin addicts and the dose response was good. This study also discusses the body-dependence potential of dihydroetorphine hydrochloride (3,7).