本文用HPLC法测定巯甲丙脯酸,最低检测浓度3μg/L。在人工胃、肠液中8h内巯甲丙脯酸基本没有变化。加EDTA后,标准液可贮存在OC12d。用转篮法测定国产糖衣片,20min前,片剂没有释药,26～40min溶出呈一级释放,释放速率0.2941min~(-1)。进口片在2min内释放95%以上,故国产片比进口片起效时间延长。 In this paper, captopril was determined by HPLC with the lowest detection concentration of 3μg / L. In the artificial stomach, gut within 8h captopril basically no change. After adding EDTA, the standard solution can be stored in OC12d. The domestic sugar-coated tablets were determined by the basket-spinning method. Before 20 minutes, the tablet did not release drug, and the first dissolution was released in 26 ~ 40 minutes. The release rate was 0.2941min ~ (-1). Imported tablets released more than 95% within 2min, so the domestic film than the import film onset time extension.