不对称二甲精氨酸(ADMA)为一氧化氮全酶(NOS)的内源性竞争性抑制剂,在动脉粥样硬化及具有动脉粥样硬化危险因素的患者的血浆中浓度明显升高,血浆ADMA水平与血管内皮功能障碍程度及动脉粥样硬化有关。已有研究表明,通过抑制一氧化氮(NO)的合成,ADMA影响血流及血管紧张度,促进动 Asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase (NOS), is significantly elevated in plasma of patients with atherosclerosis and risk factors for atherosclerosis , Plasma ADMA levels and vascular endothelial dysfunction and atherosclerosis related. It has been shown that by inhibiting the synthesis of nitric oxide (NO), ADMA affects blood flow and vascular tone,