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本研究旨在了解山东省鸡大肠杆菌耐药变化趋势,以期指导临床用药。采用96点阵药敏检测法,测定从临床上分离鉴定的2008-2014年山东省不同地区鸡场的210株大肠杆菌对14种抗生素的耐药性。结果显示,鸡源大肠杆菌对14种抗生素中的13种(多西霉素除外)的耐药性在这7年间有所增长,其中对10种抗生素的耐受性在7年间近乎翻了1倍甚至更高。根据监测结果,建议在山东地区暂停使用头孢噻呋治疗鸡大肠杆菌病,推荐使用多西霉素、大观霉素、硫酸粘菌素,将庆大霉素、新霉素、环丙沙星、恩诺沙星、氟苯尼考作为次级药物使用,并适当加大用量,应谨慎使用喹诺酮类药物和氟苯尼考。
The purpose of this study is to understand the trend of drug resistance of chicken E.coli in Shandong province in order to guide clinical drug use. Drug resistance of 210 Escherichia coli isolated from clinically isolated and identified chickens in different areas of Shandong Province from 2008 to 2014 was tested by 96-point resistive assay. The results showed that the resistance of 13 strains of Escherichia coli from 14 kinds of antibiotics (except for doxycycline) to chicken Escherichia coli increased in these 7 years, of which the resistance to 10 kinds of antibiotics nearly doubled in 1 year Times or even higher. According to the monitoring results, it is recommended to suspend the use of ceftiofur in chicken disease in Shandong Province, recommended to use doxycycline, spectinomycin, colistin sulfate, gentamicin, neomycin, ciprofloxacin, Enrofloxacin and florfenicol should be used as secondary drugs with appropriate dosage. Quinolones and florfenicol should be used with caution.