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目的探讨不同抗病毒药物方案治疗艾滋病的临床疗效及不良反应。方法方便选取120例艾滋病患者,均为2013年1月—2015年10月间收治,并随机分为研究1组、研究2组,应用含替诺福韦方案对研究1组患者实施治疗,应用含齐多夫定方案对研究两组患者实施治疗,比较两组患者治疗12个月后的CD4+T淋巴细胞计数及不良反应发生率。结果研究1组CD4+T淋巴细胞计数≥300个/μL的占60.3%%,研究2组占38.7%,研究1组CD4+T淋巴细胞计数上升幅度大于研究2组,差异有统计学意义(P<0.05)。研究1组不良反应发生4例(6.8%),研究2组不良反应发生12例(19.3%),研究2组不良反应发生率高于研究1组,差异有统计学意义(P<0.05)。结论含替诺福韦方案治疗艾滋病的疗效更可靠,不良反应更少,更具临床推广应用价值。
Objective To investigate the clinical effects and adverse reactions of different anti-viral drugs in the treatment of AIDS. Methods Convenient selection of 120 AIDS patients, were from January 2013 to October 2015 were admitted, and were randomly divided into Study Group 1, Study Group 2, the application of tenofovir-containing program to study the treatment of a group of patients, the application of With zidovudine program to study the treatment of two groups of patients, compared two groups of patients after treatment for 12 months of CD4 + T lymphocyte count and adverse reactions. Results The percentage of CD4 + T lymphocyte count in group 1 was higher than that of study group 2 (60.3 %%) and study group 2 (38.7%). The difference was statistically significant ( P <0.05). There were 4 adverse reactions (6.8%) in group 1, 12 (19.3%) cases in group 2, and 2 cases in group 2 (P <0.05). Conclusion The tenofovir-containing regimen for treating AIDS is more reliable and has fewer adverse reactions, which is more valuable in clinical application.