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目的探讨非甾体类抗炎药(NSAIDs)诱发上消化道出血(PU)的临床流行病学特点。方法调查中山大学孙逸仙纪念医院2002年1月至2009年1月间因上消化道出血收住院治疗366例患者,根据入院前1周内有无服用NSAIDs,将患者分为服药组(103例)及未服药组(263例),对两组患者的临床资料进行分析比较。结果服药组患者的年龄较未服药组更高,血红蛋白在服药组下降更明显(P<0.01);胃溃疡和复合溃疡、多发溃疡在服药组更多见(P<0.01),服药组幽门螺杆菌(Hp)的感染率与未服药组的感染率有显著差异,分别为65.05%和26.24%,(P<0.05)。结论应加强对NSAIDs相关性上消化道出血临床特点的认识,尽量减少NSAIDs的不良反应。
Objective To investigate the clinical epidemiological characteristics of non-steroidal anti-inflammatory drugs (NSAIDs) induced upper gastrointestinal bleeding (PU). METHODS: A total of 366 patients admitted to Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2002 to January 2009 were admitted to hospital for treatment of upper gastrointestinal bleeding. Patients were divided into medication group (n = 103) according to presence or absence of NSAIDs within 1 week before admission. And no medication group (263 cases), the clinical data of two groups were analyzed and compared. Results The patients in the medication group were older than those in the medication group and hemoglobin in the medication group was significantly decreased (P <0.01). Gastric ulcer, multiple ulcer and multiple ulcer were more common in the medication group (P <0.01) The infection rate of bacteria (Hp) was significantly different from that of the control group (65.05% and 26.24%, respectively) (P <0.05). Conclusions The clinical features of NSAIDs associated with upper gastrointestinal bleeding should be strengthened and the adverse reactions of NSAIDs should be minimized.