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Lidocain为氨基型局麻药,安全性大.尚有抗心律不齐作用,常用于心脏手术,治疗心肌梗塞或洋地黄中毒等.电生理学机转为降低心传导系统浦氏纤维第四相的去极化之复极,降低心室兴奋性.中毒量可诱发抽搐.痉挛反射机制即脑局部细胞过度兴奋与心室自动调节机能亢进而发生心律不齐的机制相似,有膜安定及抗痉挛作用.作者选择癫癎持续状态各种病因患者7例,年龄1～72岁,男4例,女3例.总结疗效特点:①速效:一次静注后20～30秒抽搐停止,疗效持续时间约20分钟.②不降低意识水平.③向维持治疗过渡:用量4毫克/公斤/小时,保持数小时至24小时,有一例达36小时.④安全:7例按2～3毫克/公斤一次静注和4毫克/公斤/小时,24小时持续静滴,无生命征变化/作者指出,痉挛原电生理机转尚不明,但已知发生无规律的异常电活动系痉挛原细胞膜通透性异常所致.Sakabe观察,局麻药对血脑屏障并无影响,
Lidocain is an amino type of local anesthetic, safety. There are anti-arrhythmic effect, commonly used in cardiac surgery, myocardial infarction or digitalis poisoning, etc. Electrophysiology machine to reduce cardiac conduction system, the fourth phase of fiber to go Polarization of the complex and reduce ventricular excitability. Toxicity can induce convulsions. Spasm reflex mechanism that brain cells over-excitement and ventricular autoregulation and arrhythmias occur arrhythmia mechanism similar to a membrane stability and anti-spasticity. Select the status of epileptic seizures in 7 patients with various causes, aged 1 to 72 years old, 4 males and 3 females.Conclusion Efficacy features: ① quick effect: 20 to 30 seconds after a stop of convulsions, the duration of treatment of about 20 minutes .② do not reduce the level of consciousness.③To maintain the transition to treatment: the amount of 4 mg / kg / hour, keep a few hours to 24 hours, a case of up to 36 hours .④ Safety: 7 cases by 2 to 3 mg / kg intravenous and 4 mg / kg / h, continuous intravenous infusion 24 hours, no signs of life-threatening changes / The authors point out that the original electrophysiological spasm mechanism is not yet known, but is known to occur irregular abnormal electrical activity spasm cell membrane permeability caused by abnormalities Sakak observation, local anesthetic on the blood brain screen Barrier has no effect