肝脏是体内最活跃的代谢器官,它几乎参与体内全部物质代谢过程,还具有防御、解毒和排泄等各种机能。药物进入人体后在肝内经氧化、还原、水解、结合及转运等方式进行解毒,并最终从粪便或尿中排出。由于绝大多数的药物是在肝内代谢的,因此药物或其代谢产物可引起肝脏不良反应,特别是对原已有肝脏疾病的患者更为常见。有人估计目前肝脏病患者中约有20％是由药物所 The liver is the body’s most active metabolic organs, it is involved in almost all of the material metabolism in the body, but also has a variety of defense, detoxification and excretion and other functions. Drugs enter the human body in the liver after oxidation, reduction, hydrolysis, binding and transport methods such as detoxification, and eventually excreted from the feces or urine. Because the vast majority of drugs are metabolized in the liver, drugs or their metabolites can cause adverse reactions in the liver, especially in patients with liver disease. It is estimated that about 20% of current liver disease patients are drugged