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恶性黑色素瘤的早期主要是手术治疗,药物治疗主要用于手术后的辅助治疗和不能手术的或/和晚期播散性病变。近年来通过广泛的临床Ⅱ、Ⅲ期实验,筛选了一批比较有效联合化疗方案,加之免疫治疗和内分泌治疗的发展和应用,使得晚期恶性黑色素瘤的治疗状况大有改观,本文根据近年报道的文献,对此进行扼要的概述。一、化学治疗 (一)单药治疗:黑色素瘤的各药疗效均不佳,已试用过的各种常用抗癌药物有环磷酰胺(CTX),噻(口替)(口派)(TSPA)、氮芥(HN_2),苯丙氨酸氮芥
The early stage of malignant melanoma is mainly surgical treatment. Drug therapy is mainly used for post-operative adjuvant therapy and inoperable or/and advanced disseminated disease. In recent years, extensive clinical phase II and phase III trials have screened a number of more effective combined chemotherapy regimens, coupled with the development and application of immunotherapy and endocrine therapy, which has greatly improved the treatment status of advanced malignant melanoma. This article has been reported in recent years. Literature, an overview of this. I. Chemotherapy (1) Monotherapy: The efficacy of various melanoma drugs is poor, and various common anticancer drugs that have been tried include cyclophosphamide (CTX), thiophene (oral) (oral) (TSPA ), nitrogen mustard (HN_2), phenylalanine nitrogen mustard