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目的研究黏着斑激酶(FAK)和血管内皮生长因子-C(VEGF-C)在乳腺癌组织中的表达,探讨其与肿瘤淋巴转移的关系及两者的相关性。方法应用免疫组织化学SP法检测92例乳腺癌组织和30例乳腺良性病变组织中FAK、VEGF-C的表达情况。结果92例乳腺癌组织中FAK和VEGF-C的阳性表达率分别为69.6%和46.7%,与良性对照组比较,差异有统计学意义(P<0.01);FAK的阳性表达与乳腺癌肿瘤大小、腋窝淋巴结转移、临床分期呈正相关(P<0.01),VEGF-C的表达与乳腺癌腋窝淋巴结转移、临床分期呈正相关(P<0.05);乳腺癌组织FAK和VEGF-C的表达呈正相关(P<0.01,列联系数C=0.3952)。结论FAK和VEGF-C蛋白的表达与乳腺癌淋巴转移密切相关,FAK可能通过上调VEGF-C的表达,增强其淋巴管生成作用,进而促使乳腺癌细胞的淋巴转移。
Objective To study the expression of focal adhesion kinase (FAK) and vascular endothelial growth factor-C (VEGF-C) in breast cancer and to explore the relationship between FAK and lymphatic metastasis and their relationship. Methods The expression of FAK and VEGF-C in 92 cases of breast cancer and 30 cases of benign breast lesions were detected by immunohistochemical SP method. Results The positive rates of FAK and VEGF-C in 92 cases of breast cancer were 69.6% and 46.7%, respectively, which were significantly different from those in benign control group (P <0.01). The positive expression of FAK and VEGF in breast cancer (P <0.01). The expression of VEGF-C was positively correlated with axillary lymph node metastasis and clinical stage in breast cancer (P <0.05). There was a positive correlation between the expression of FAK and VEGF-C in breast cancer P <0.01, C = 0.3952). Conclusions The expression of FAK and VEGF-C protein is closely related to lymphatic metastasis in breast cancer. FAK may promote the lymphatic metastasis of breast cancer cells by up-regulating the expression of VEGF-C and enhancing its lymphangiogenesis.