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目的:探讨影响冻融胚胎移植(FET)妊娠结局的相关因素。方法:回顾性分析324个周期行FET患者的临床资料,分析患者年龄、体质量指数(BMI)、移植日子宫内膜厚度、内膜准备方案、移植胚胎数等相关因素对FET妊娠结局的影响。结果:324个周期共解冻胚胎727个,复苏成活720个(99.0%),临床妊娠144例(44.4%),胚胎植入196例(27.2%)。其中自然内膜准备周期组和激素替代内膜准备周期组患者年龄、不孕年限、基础卵泡刺激素(bFSH)、基础黄体生成素(bLH)、基础雌二醇(bE2)、复苏胚胎数、移植胚胎数、移植日子宫内膜厚度、胚胎种植率及临床妊娠率组间均无统计学差异(P>0.05)。年龄≤35岁组的临床妊娠率高于年龄>35岁组,差异有统计学意义(P<0.05);BMI≥24.0 kg/m2的肥胖组临床妊娠率与正常体质量(BMI=18.5~23.9 kg/m2)组无统计学差异(P>0.05);移植日子宫内膜厚度≥7 mm组的临床妊娠率高于移植日子宫内膜厚度<7 mm组,但差异无统计学意义(P>0.05);各移植胚胎数组间临床妊娠率无统计学差异(P>0.05)。结论:年龄是影响FET临床结局的重要因素,内膜准备方案、BMI、移植日内膜厚度、移植胚胎数对冻融胚胎移植临床结局无影响。
Objective: To explore the factors influencing pregnancy outcome of frozen-thawed embryo transfer (FET). Methods: The clinical data of 324 FET patients were retrospectively analyzed. The influence of FET age, body mass index (BMI), endometrial thickness on transplantation day, endometrial preparation plan and number of embryos transferred on FET pregnancy outcome were analyzed retrospectively . Results: A total of 727 embryos were thawed in 324 cycles, with 720 (99.0%) surviving and resuscitation, 144 (44.4%) pregnant and 196 (27.2%) embryos implanted. Among them, the age of patients, age of infertility, basal follicle stimulating hormone (bFSH), basal body luteinizing hormone (bLH), basal estradiol (bE2), number of embryos resuscitated, There were no significant differences in the number of embryos transferred, endometrial thickness at implantation, embryo implantation rate and clinical pregnancy rate (P> 0.05). The clinical pregnancy rate in the group of ≤35 years old was higher than that in the group of> 35 years old (P <0.05). The clinical pregnancy rate and the normal body weight (BMI = 18.5-23.9) in obesity group with BMI≥24.0 kg / m2 kg / m2) group (P> 0.05). The clinical pregnancy rate of endometrial thickness≥7 mm group on transplantation day was higher than that of endometrial thickness less than 7 mm on transplantation day (P> 0.05), but the difference was not statistically significant > 0.05). There was no significant difference in clinical pregnancy rates among the transplanted embryos (P> 0.05). Conclusion: Age is an important factor affecting the clinical outcomes of FET. Endometrial preparation, BMI, endometrial thickness at transplantation, and the number of embryos transferred have no effect on the outcome of frozen-thawed embryo transfer.