论文部分内容阅读
选取自2013年9月至2015年10月在南京市妇幼保健院及南京市江宁医院妇科病房收治的患者血清标本。其中卵巢癌71例,宫颈癌62例,子宫内膜癌57例,同时选取53例健康女性作为对照。利用罗氏电化学发光法和ELISA法检测肿瘤患者和健康对照组妇女的血清中CA125和HE4的水平,并用灵敏度和特异度评价血清HE4和CA125联合检测的效能。71例卵巢癌患者中,有48例患者血清中的CA125和HE4水平均明显高于健康对照组(p<0.05)。62例宫颈癌患者中,有47例患者血清中的CA125和HE4的水平均明显高于健康对照组(p<0.05)。57例子宫内膜癌患者中,有43例患者血清中的CA125和HE4的水平均明显高于健康对照组(p<0.05)。HE4和CA125联合检测的灵敏度和特异度明显高于单项检测。妇科肿瘤患者血清中HE4和CA125联合检测有更为明显的优势性,其灵敏度和特异性比单独检测更为高效,可明显提高妇科肿瘤患者的临床诊断准确性,为进一步的治疗提供了更为精准的信息。
Selected from September 2013 to October 2015 in Nanjing Maternal and Child Health Hospital and Nanjing Jiangning Hospital gynecological ward admitted patients with serum samples. Among them, 71 cases of ovarian cancer, 62 cases of cervical cancer, 57 cases of endometrial cancer, while 53 healthy women were selected as a control. Roche electrochemiluminescence and ELISA were used to detect the levels of CA125 and HE4 in the serum of women with cancer and healthy controls. The sensitivity and specificity of the combined detection of serum HE4 and CA125 were also evaluated. Serum levels of CA125 and HE4 in 48 of 71 ovarian cancer patients were significantly higher than those in healthy controls (p <0.05). The serum levels of CA125 and HE4 in 47 of 62 cervical cancer patients were significantly higher than those in healthy controls (p <0.05). In 57 cases of endometrial cancer, serum levels of CA125 and HE4 in 43 patients were significantly higher than those in healthy controls (p <0.05). The sensitivity and specificity of the combined detection of HE4 and CA125 were significantly higher than those of single detection. Gynecologic oncology patients with HE4 and CA125 serum combined with more obvious advantages, its sensitivity and specificity more efficient than the single test can significantly improve the clinical diagnosis of gynecologic oncology patients, for further treatment provides more Precise information.