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眼睑恶性肿瘤是眼科常见病,其中眼睑基底细胞癌、鳞状细胞癌及眼睑皮脂腺癌最多见,并称眼睑3大恶性肿瘤。随着分子生物学技术的发展,研究发现多种因素参与眼睑恶性肿瘤发病过程,与其发病有关的癌基因、抑癌基因、细胞凋亡相关基因、细胞增殖相关因子、粘附因子、基底膜蛋白、端粒酶等,这些基因和蛋白的变异与眼睑恶性肿瘤的发生发展、分化程度、浸润转移、预后等密切相关。
Malignant eyelid is a common ophthalmology, including eyelid basal cell carcinoma, squamous cell carcinoma and eyelid sebaceous carcinoma is the most common, and said the eyelid 3 major malignant tumors. With the development of molecular biology techniques, many factors have been found involved in the pathogenesis of eyelid malignancies, including oncogenes, tumor suppressor genes, apoptosis related genes, cell proliferation related factors, adhesion factors, basement membrane proteins , Telomerase, etc. The variation of these genes and proteins is closely related to the occurrence and development, differentiation, invasion and metastasis, prognosis of eyelid malignancies.