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研究人员近日发现了一些白血病比其它类型白血病更具浸润性和致死性的新线索,该线索源自于患者自身的遗传受损,表现为血液细胞不受控制的生长。美国St.Jude儿童医院Howard Hughes医学研究所的Charles J.Sherr医生及其同事报道说,这一发现将可能有助于医生了解一些癌症能够至少暂时性地受到药物控制而有些癌症却对治疗药物产生抵抗性的原因所在。Sherr医生与Riehaid T WiIIrams博士在近期出版的《美国国立研究院会刊》上指出,两种遗传异常的组合将使得肿瘤浸润能力几乎扩大1000倍;并对慢性粒细胞性白血病(简称慢粒,CML)和亚型
Researchers have recently uncovered new clues to some leukemias that are more invasive and lethal than other types of leukemia stemming from the patient’s own genetic impairment manifested by uncontrolled growth of blood cells. Charles J. Sherr and colleagues at the Howard Hughes Medical Institute at St. Jude Children’s Hospital in the U.S. reported that the finding could help doctors understand that some cancers can be at least temporarily controlled by drugs and that some can treat therapies Reasons for the emergence of resistance. In a recent issue of the Proceedings of the National Academy of Sciences, Dr. Sherr and Dr. Riehaid T Willrams pointed out that the combination of two genetic anomalies will increase the ability of tumor infiltrates to almost 1000-fold; and that chronic myelogenous leukemia (CML, CML) and subtype