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通过引入蛋白游离率（ Ｅｆ） 的比较取代基常数（ Ｃｆ） ， 其定义为 Ｃｆ ＝ Ｌｏｇ Ｅｘ／ Ｅ Ｈ， 计算了碘代芳香胺系列物的蛋白游离率（ Ｅｆ） 的比较取代基常数 （ Ｃｆ） 。结果表明取代基不同， Ｃｆ 数值不同。对一定的基团为常数，且具有加和性。该结果可用于评价药物取代基对蛋白游离率的贡献和药物的药效， 以及计算碘代芳香胺的 Ｅｆ值。
The comparative substituent constants (Cf) were calculated by introducing a comparative substituent constant (Cf) defined as Cf = Log Ex / E H for the protein free rate (Ef) ). The results show that the different substituents, Cf values are different. Certain groups are constant and additive. This result can be used to evaluate the contribution of drug substituents to the protein free rate and the efficacy of the drug, as well as to calculate the Ef values for iodoarylamine.