胶质瘤是神经外科研究工作的主要方向,其中针对胶质母细胞瘤的研究是恶性肿瘤研究的焦点之一,该类患者中位生存期仅为14.6个月,5年相对生存率不到5%,是癌症基因图谱研究组(TCGA)首批进行基因拷贝数、基因组甲基化变异,核苷酸变异序列检测的重要研究对象~([1])。2001年人类基因组计划的基因测序完成~([2-3])。得益于计算机技术的高速发展,肿瘤研究已进入高通量 Glioma is the main direction of neurosurgery research, of which the study of glioblastoma is one of the focuses of malignant tumors, the median survival of these patients was only 14.6 months, 5-year relative survival rate less than 5%. It is one of the first research objects in the Cancer Genome Research Group (TCGA) to detect gene copy number, genomic methylation variation and nucleotide variation sequence (1). Genome sequencing of the human genome project completed in 2001 ~ ([2-3]). Benefit from the rapid development of computer technology, cancer research has entered a high-throughput