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目的 探讨睡眠剥夺条件下服用咖啡因对情绪情感状态的影响。 方法 ８ 名受试者用药前后自身对照，每名受试者重复５ 次间隔至少１ 周的实验，每次实验中在从６：００ 至次日９：００ 的２７ ｈ 的睡眠剥夺过程中于凌晨１：００ 分别服用安慰剂（食用淀粉１０ ｍ ｇ）或咖啡因（ ２００ ｍ ｇ 或 ３００ｍ ｇ）或苯丙胺（５ ｍ ｇ 或１０ ｍ ｇ），采用随机双盲给药。并在服药前１ ｈ 及服药后１ ｈ、３ ｈ、５ ｈ、７ ｈ 各完成一组情绪情感状态的测试。 结果 与安慰剂组比较，咖啡因能有效地克服睡眠剥夺后情绪情感状态量表（ＰＯＭＳ）中的“有力－好动”（Ｖ）得分的降低（Ｐ＜ ０．０５），克服“疲惫－惰性”（Ｆ）和“困惑－迷茫”（Ｃ）得分的升高（Ｐ＜ ０．０５）；服用咖啡因后主观困倦程度降低（Ｐ＜ ０．０５） 。２００ ｍ ｇ 与３００ ｍ ｇ 咖啡因组间无显著差异（Ｐ＜ ０．０５）。 结论 咖啡因２００ ｍ ｇ 和咖啡因３００ ｍ ｇ 对于睡眠不足和睡眠剥夺引起的情绪情感状态的恶化具有明显的改善作用
Objective To investigate the effects of taking caffeine on mood and emotional state under sleep deprivation. Methods Eight subjects were self-controlled before and after treatment. Each subject repeated 5 times at least one week interval. In each experiment, during 27 h sleep deprivation from 6:00 to 9:00 Placebo (placebo 10 m g) or caffeine (200 m g or 300 m g) or amphetamine (5 m g or 10 m g) at 1:00 am, respectively, in a randomized double-blind dose. And a group of emotional emotional state tests were completed at 1 h before taking medicine and 1 h, 3 h, 5 h, 7 h after taking the medicine. Results Compared with the placebo group, caffeine was able to effectively reduce the “Vigor-Active” (V) score in POMS after sleep deprivation (P <0.05) and overcome the "exhaustion- (P <0.05). The subjective drowsiness decreased after taking caffeine (P <0.05). There was no significant difference between 200 m g and 300 m g caffeine groups (P <0.05). Conclusion Caffeine 200 m g and caffeine 300 m g have a significant effect on the deterioration of emotional state caused by lack of sleep and sleep deprivation