Second pregnancy of trisomy 21 in a mother with mosaicism

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In the case of a previous offspring with trisomy 21,recurrence risk for Down syndrome is about 1%.1 It may be due to chance, but the possibility of germline mosaicism for trisomy 21 in one of the parents has important implications for the recurrence. Here we report a young healthy mother, who has a second pregnancy of trisomy 21.
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