论文部分内容阅读
目的:探讨通塞脉片灌胃给药对大鼠慢性低灌注脑损伤的保护作用。方法:将大鼠随机分为三个小组,包括假手术组,模型组和治疗组,模型组与治疗组构建大鼠慢性低灌注(2VO)模型,治疗组给予通塞脉灌胃治疗(12.44g/kg.d),后进行Morris水迷宫试验,对实验对象的空间认知能力和记忆力做出判断。结果:慢性低灌注大鼠模型潜伏时间较长,游泳路程较长,平台象限时间较短,通过通塞脉片治疗的实验组随着治疗时间的延长,水迷宫实验结果有所改善。结论:通塞脉片能够减少慢性低灌注的脑损伤。
Objective: To investigate the protective effect of Tongsaimai tablet on chronic cerebral hypoperfusion injury in rats. Methods: The rats were randomly divided into three groups: sham operation group, model group and treatment group. Model of chronic low-perfusion (2VO) rats was established in model group and treatment group, and treatment group received Tongzaimai intragastric administration (12.44 g / kg.d). Morris water maze test was performed to judge the spatial cognition and memory of the experimental subjects. Results: Chronic hypoperfusion rat model had longer latent period, longer swimming distance and shorter platform quadrant time. Experimental group treated with Tongsai Mai tablet improved the results of water maze as the treatment time prolonged. Conclusion: Tongsaimailian tablet can reduce the chronic hypoperfusion brain damage.