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目的探讨三七总皂苷(PNS)对老年性痴呆(AD)模型大鼠空间学习记忆功能障碍的改善作用。方法以D-半乳糖腹腔注射致亚急性损伤合并鹅膏蕈氨酸损毁双侧大脑Meynert基底核建立AD大鼠动物模型;Morris水迷宫进行学习记忆能力检测。结果PNS高、低剂量组大鼠在Morris水迷宫测试中,逃避潜伏期明显缩短,寻求次数、原平台象限比、跨越原平台次数明显增加,与模型组比较有显著意义(P<0.05)。结论PNS对AD模型大鼠空间学习记忆损害具有明显改善作用。
Objective To investigate the improving effect of Panax notoginseng saponins (PNS) on spatial learning and memory dysfunction in senile dementia (AD) rats. Methods Animal models of Alzheimer’s disease were established by intraperitoneal injection of D-galactose to induce subacute lesions and amygdalin to damage the basal ganglia of Meynert. The Morris water maze was used to test the ability of learning and memory. Results The evasion latency in the Morris water maze test was significantly shorter in PNS high- and low-dose group rats, and the number of seeks, the ratio of the original platform quadrant, and the number of crossings of the original platform were significantly increased, which was significant compared with the model group (P<0.05). Conclusion PNS can significantly improve spatial learning and memory impairment in AD rats.