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吡喹酮已广泛用于各种血吸虫感染的治疗。实验研究显示,血吸虫经数代重复暴露于亚治疗量的吡喹酮可产生耐药性。在埃及大规模重复使用吡喹酮已逾10年,因此有产生耐药性的可能。影响吡喹酮疗效的除血吸虫自身因素外,还有宿主因素。首先,宿主免疫系统在杀死被吡喹酮损伤的血吸虫的过程中起重要作用,常规剂量的吡喹酮不能杀死寄生于免疫缺陷动物体内的血吸虫;其次,吡喹酮对血吸虫童虫的敏感性较低。此外,宿主对吡喹酮代谢的差异导致疗效的不同。因此,要证明血吸虫对吡喹酮的耐药性必须排除宿主
Praziquantel has been widely used in the treatment of various schistosome infections. Experimental studies have shown that after several generations of repeated exposure Schistosoma japonicum praziquantel sub-therapeutic drug-resistant. Praziquantel has been used extensively in Egypt for over 10 years and is therefore likely to develop resistance. Affect praziquantel efficacy in addition to the schistosoma factor itself, there are host factors. First, the host immune system plays an important role in killing schistosomes damaged by praziquantel. Praziquantel can not kill schistosomes that parasitize immunodeficient animals. Second, praziquantel has no effect on schistosomula Sensitivity is low. In addition, differences in the host metabolism of praziquantel result in different therapeutic effects. Therefore, to prove that schistosoma resistance to praziquantel must exclude the host