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目的观察阿托伐他汀预防蛛网膜下腔出血后症状性脑血管痉挛的疗效。方法 47例自发性蛛网膜下腔出血患者随机分为研究组(24例)和对照组(23例),研究组在常规治疗基础上加用阿托伐他汀20mg/d,对照组予常规治疗,比较两组患者大脑中动脉的血流速度以及症状性脑血管痉挛和迟发性脑梗塞的发生情况。结果研究组患者大脑中动脉的平均血流速度在发病第7d和第14d时均明显慢于对照组,差异有统计学意义(P<0.05);研究组脑血管痉挛和症状性脑血管痉挛均明显低于对照组,差异有统计学意义(P<0.05),但迟发性脑梗塞发生率与对照组之间比较差异无统计学意义(P>0.05)。结论阿托伐他汀可以减少蛛网膜下腔出血后症状性脑血管痉挛的发生。
Objective To observe the effect of atorvastatin on preventing symptomatic cerebral vasospasm after subarachnoid hemorrhage. Methods Forty-seven patients with spontaneous subarachnoid hemorrhage were randomly divided into study group (24 cases) and control group (23 cases). The study group was given atorvastatin 20 mg / d on the basis of routine treatment, while the control group was given routine treatment The blood flow velocity of the middle cerebral artery and the occurrence of symptomatic cerebral vasospasm and delayed cerebral infarction were compared between the two groups. Results The average velocity of blood flow in the middle cerebral artery of the study group was significantly lower than that of the control group on the 7th day and the 14th day of onset (P <0.05). Both of the study group had cerebral vasospasm and symptomatic cerebral vasospasm (P <0.05), but there was no significant difference between the incidence of delayed cerebral infarction and the control group (P> 0.05). Conclusions Atorvastatin can reduce the incidence of symptomatic cerebral vasospasm after subarachnoid hemorrhage.