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目的：探讨心力衰竭（HF）患者血浆N-末端脑钠肽（NT-proBNP）与心功能严重程度的相关性，评价其对心力衰竭患者的临床意义。方法：心力衰竭患者140例，按纽约心脏病协会（NYHA）心功能分级，其中NYHAⅡ级52例、Ⅲ级56例、Ⅳ级32例，同时选取68例心功能正常人作为对照组，分别测定血浆NT-proBNP值及左室射血分数（LVEF）。结果心力衰竭组NT-proBNP数值明显高于对照组，且其数值随心功能分级的升高而增高，与LVEF呈负相关（P＜0.05）。结论心力衰竭患者血NT-proBNP水平与心力衰竭严重程度存在相关性，可客观反映心力衰竭患者的心功能状态。“,”Objective To investigate the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with the deterioration of the heart failure severity. Methods 140 patiants with heat failure were selected among them( 52 subjets with NYHAⅡ,56subjets with NYHA Ⅲ,32 subjets with NYHA Ⅳ), and 68 subjets were enrol ed in contorl group. The plasma level of NT-proBNP were detected by electrochemiluminescence immunoassay methed,and the structure and fuction of left ventricle were examined by echocardiography. Results The plasma level of NT-proBNP increased significantly in patients with heart failure compard with control groups,and the dregreed of NYHA.The levels of plasma NT-proBNP were negatively correlated with LVEF.Conclusions The plasma level of NT-proBNP has the realationship with the deterioration of the heart failure severity,and it can be used to evaluate the function in the elderly patients with heart failure.