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雷帕霉素 (ｒａｐａｍｙｃｉｎ ,ＲＰＭ )是 2 0世纪 70年代初 ,由加拿大Ａｙｅｒｓｔ研究所从放线菌 (Ｓｔｒｅｐｔｏｍｙｃｅｓｈｙｇｒｏｓｃｏｐｉｃｕｓ)培养液中分离出来的大环内酯类抗生素[1,2 ] 其相对分子质量为 914 2。 2 0世纪 70年代末期 ,Ｍａｒｔａｌ等首先发现
Rapamycin (RPM) was a macrolide antibiotic isolated from Streptomyces hygroscopicus culture by the Ayerst Institute in Canada in the early 1970s [1,2]. Its relative molecular mass 914 2. In the late 1970s, Martal et al. First discovered